Suruchi Verma, Vikas Kumar



Turmeric (Curcuma longa ) is a medicinal plant of the family Zingiberaceae widely growing throughout India. Turmeric oil is secondary metabolite of turmeric and obtained by steam distillation of its rhizomes. Turmeric oil a lipophilic fraction from turmeric, exhibits several therapeutic potentials. Turmeric oil chiefly comprises arturmerone and β-turmerone. During more recent decades broad spectrums of therapeutically interesting pharmacological properties of turmeric and its secondary metabolites have been reported. Recent several efforts made to explore the pharmacological profile and mechanism of action of turmeric revealed exceptionally broad spectrums of pharmacological activity profiles of turmeric oil. It is now well recognized that additive or synergistic interactions between diverse combinations of phytochemicals are involved in health benefits of vegetarian diets and herbal remedies and that regular consumption of appropriate combinations of some such edible phytochemicals with every day meals could as well be used for prevention and cure of different health problems. Critical analysis of available preclinical and clinical information on turmeric oil strongly suggests it is pharmacologically polyvalent and possess several pharmacological properties. Aim of this communication is to summarize and critically analyze such data, and to point out some possibilities for more rationally exploiting their therapeutic potential for discovering novel therapeutic leads, or for obtaining pharmacologically better standardized phyto-pharmaceuticals.


Curcuma longa; Turmeric oil; lipophilic; phyto-pharmaceuticals

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Singh S (2007). From exotic spice to modern drug? Cell. 130: 765-768.

Liju VB., Jeena K., Kuttan R (2011). An evaluation of antioxidant, antiinflammatory, and antinociceptive activities of essential oil from Curcuma longa. L. Indian Journal of Pharmacology, 43(5): 526–531.

Sacchetti G., Maietti S., Muzzoli M., Scaglianti M., Manfredini S., Radice M (2005). Comparative evaluation of 11 essential oils of different origins as functional antioxidants, antiradicals and antimicrobials in foods. Food Chemistry, 91(4): 621- 632.

Negi PS., Jayaprakasha GK., Jagan Mohan RL, Sakariah KK (1999). Antibacterial activity of turmeric oil: a byproduct from curcumin manufacture. Journal of Agricultural and Food Chemistry, 47(10): 4297–4300.

Jayaprakasha GK, Jena, B.S., Negi, P.S., Sakariah, K.K., 2002. Evaluation of antioxidant activities and antimutagenicity of turmeric oil: a byproduct from Curcumin production. Zeitschrift für Naturforschung C, 57(9): 828–835.

Prakash P., Misra A., Surin WR., Jain M., Bhatta RS., Pal R., Barthwal MK., Dikshit M (2011). Anti-platelet effects of curcuma oil in experimental models of myocardial ischemia-reperfusion and thrombosis. Thrombosis Research, 127(2): 111-118.

Funk JL., Frye JB., Oyarzo JN., Zhang H., Timmermann MN (2010). AntiArthritic effects and toxicity of the essential oils of turmeric (Curcuma longa L). Journal of Agricultural and Food Chemistry, 58(2): 842-849.

Jain V., Prasad V., Pal R., Singh S (2007). Standardization and stability studies of neuroprotective lipid soluble fraction obtained from Curcuma longa. Journal of Pharmaceutical and Biomedical Analysis, 44(5): 1079-1086.

Dohare P., Garg P., Sharma U., Jagannathan NR., Ray M (2008a). Neuroprotective efficacy and therapeutic window of curcuma oil: in rat embolic stroke model. BMC Complementary and Alternative Medicine, 8:55.

Rathore P., Dohare P., Varma S., Ray A., Sharma U., Jagannathan NR., Ray M (2008). Curcuma oil: reduces early accumulation of oxidative product and is antiapoptogenic in transient focal ischemia in rat brain. Neurochemical Research, 33(9):1672-1682.

Das DA., Balan A., Sreelatha, KT (2010). Comparative study of the efficacy of curcumin and turmeric oil as chemopreventive agents in oral submucous fibrosis: a clinical and histopathological evaluation. Journal of Indian Academy of Oral Medicine & Radiology, 22: 88-92.

Hastak K., Lubri N., Jakhi SD., More C., John A., Ghaisas SD., Bhide SV (1997). Effect of turmeric oil and turmeric oleoresin on cytogenetic damage in patients suffering from oral submucous fibrosis. Cancer Letters, 116: 265-269.

Ray MPR., Singh S., Khanna NM (2006). Herbal medicaments for the treatment of neurocerebrovascular disorders.

Antony B., Merina B., Iyer VS., Judy N., Lennertz K., Joyal S (2008). A pilot crossover study to evaluate human oral bioavailability of BCM-95 CG (Biocurcumax), a novel bioenhanced preparation of curcumin. Indian Journal of Pharmaceutical Sciences, 70(4): 445-449.

Sasaki YF., Kawaguchi S., Kamaya A., Ohshita M., Kabasawa K., Iwama K., Taniguchi K., Tsuda S (2002). The comet assay with 8 mouse organs: results with 39 currently used food additives. Mutation Research, 519: 103-119.

Bowles EJ (2004). The Chemistry of Aromatherapeutic Oils, third ed. Allen and Unwin Academic, Crows Nest, NSW.

Singh S., Bhawani S., Sathpathy R., Kumar S., Enketeswara S., Nayak S (2011). Chemical composition of turmeric oil (Curcuma longa L.) and its antimicrobial activity against eye infecting pathogens. Journal of Essential Oil Research, 23(6): 11-18.

Liju VB., Jeena K., Kuttan R (2014). Chemopreventive activity of turmeric essential oil and mechanisms of Action.Asian Pacific Journal of Cancer Prevention, 15(16): 6575-6580.

Dohare P., Varma S., Ray M (2008b). Curcuma oil modulates the nitric oxide system response to cerebral ischemia/reperfusion injury. Nitric Oxide, 19(1): 111.

Singh V, Jain M, Misra A, Khanna V, Rana M., Prakash P., Malasoni R et al., (2013). Curcuma oil ameliorates hyperlipidaemia and associated deleterious effects in golden Syrian hamsters. British Journal of Nutrition, 110:437-446.

Ling J., Wei B., Lv G., Ji H., S Li (2012). Anti-hyperlipidaemic and antioxidant effects of turmeric oil in hyperlipidaemic rats. Food Chemistry, 130: 229-235.

Singh V., Rana M., Jain M., Singh N., Naqvi A., Malasoni R., Dwivedi AK et al. (2014). Curcuma oil attenuates accelerated atherosclerosis and macrophage foam-cell formation by modulating genes involved in plaque stability, lipid homeostasis and inflammation. British Journal of Nutrition, 113:100-113.

Singh V., Jain M., Misra A ., Khanna V., Prakash P., Malasoni R., Dwivedi AK et al., (2015). Curcuma oil ameliorates insulin resistance & associated thrombotic complications in hamster & rat. Indian Journal of Medical Research, 141:823-832.

Cheng JJ., YangLW., Lin JL., Dai GX., Zhu JY (2014).Effects of zedoary turmeric oil on Nai-Bin P450 activities in rats with liver cirrhosis induced by thioacetamide.International Journal of Clinical and Experimental Pathology, 7(11):7854-7862.

Zhao L., Zhang H., Yang Y., Zheng Y., Dong M, Wang Y, Bai G et al. (2014). Serum Metabonomic analysis of protective effects of Curcuma aromatica oil on renal fibrosis rats. PLoS ONE, 29: 9(9):e108678. doi:10.1371/journal.pone.0108678.

Aplsarlyakul A., Vanittanakom N,. Buddhasukh D (1995). Antifungal activity of turmeric oil extracted from Curcuma longa (Zingiberaceae). Journal of Ethnopharmacology, 49:163-169.

Mukda J., Wuthi M., Gritsanapan W (2013). Antidermatophytic Properties of Ar-Turmerone, Turmeric Oil, and Curcuma longa Preparations. Hindawi Publishing Corporation ISRN Dermatology, Article ID 250597, 1-3.

Ferreira FD., Kemmelmeier C., Arroteia CC., Costa CL., Mallmann CA., Janeiro V., Ferreira FM, et al. (2013). Inhibitory effect of the essential oil of Curcuma longa L. and curcumin on aflatoxin production by Aspergillus flavus Link. Food Chemistry, 136:789-793.

Reza SM., Rahman AA., Sattar MA., Rahman MO., Fida HM (2010). Essential oil composition and antioxidant activities of Curcuma aromatica Salisb. Food and Chemical Toxicology, 48: 1757-1760.

Kim D., Suh Y., Lee H., Lee Y (2013). Immune activation and antitumor response of ar-turmerone on P388D1 lymphoblast cell implanted tumors. International Journal of Molecular Medicine, 31: 386-392.

Baik KU., Jung SH., Ahn BZ (1993). Recognition of pharmacophore of arturmerone for its anticancer activity. Archives of Pharmacal Research, 16: 254256.

Nishiyama T., Mae T., Kishida H., Tsukagawa M., Mimaki Y., Kuroda M., Sashida Y et al. (2005). Curcuminoids and sesquiterpenoids in turmeric (Curcuma longa L.) suppress an increase in blood glucose level in type 2 diabetic KK-Ay mice. Journal of Agricultural and Food Chemistry, 53: 959963.

Lee HS (2006). Antiplatelet property of Curcuma longa L. rhizome-derived arturmerone. Bioresource Technology, 97: 1372-1376.

Liao JC., Tsai JC., Liu CY., Huang HC., Wu LY., Peng WH (2013). Antidepressant-like activity of turmerone in behavioral despair tests in mice. BMC Complementary and Alternative Medicine, 13: 299.

Yue GGL., Chan BC., Hon PM., Lee MY., Fung KP., Leung PC., Lau CBS (2010). Evaluation of in vitro antiproliferative and immunomodulatory activities of compounds isolated from Curcuma longa. Food and Chemical Toxicology, 48(8-9): 2011-2020.

Yue GGL., Cheng SW., Yu H., Xu ZS., Lee JKM., Hon PM., Lee MY et al. (2012). The Role of turmerones on curcumin transportation and P-glycoprotein activities in intestinal caco-2 cells. Journal of Medicinal Food, 15 (3): 242–252.

Joshi J., Ghaisas S., Vaidya A., Vaidya R., Kamat DV., Bhagwat AN., Bhide S (2003). Early Human safety study of turmeric oil (Curcuma longa oil) administered orally in healthy volunteers. Journal of the Association of Physicians of India, 51:1055-1060.

Liju VB., Jeena K., Kuttan R (2013). Acute and subchronic toxicity as well as mutagenic evaluation of essential oil from turmeric (Curcuma longa L). Food and Chemical Toxicology, 53: 52-61.

Orellana P., Afrikanova AM., Thomas T., Aibuldinov J., Dehaen YK., Witte PA., Esguerra CV (2013). Insights from zebrafish and mouse models on the activity and safety of ar-turmerone as a potential drug candidate for the treatment of epilepsy. PLoS ONE, 13:8(12):e81634 doi: 10.1371/journal.pone.0081634.

Mingjie J., Choi J., Lee J., Lee Y (2004). Induction of apoptosis by arturmerone on various cell lines. International Journal of Molecular Medicine, 14: 253-256.


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