Research Article
Authors: Tatjana Ćebović (University of Novi Sad, Faculty of Medicine, Department of Biochemistry, Novi Sad, Serbia) , Jelena Vladić (University of Novi Sad, Faculty of Technology, Department of Biotechnological and Pharmaceutical Engineering, Novi Sad, Serbia) , Aleksandra Gavarić (University of Novi Sad, Novi Sad, Faculty of Technology, Department of Biotechnological and Pharmaceutical Engineering, Serbia) , Zoran Zekanović (University of Novi Sad, Novi Sad, Faculty of Technology, Department of Biotechnological and Pharmaceutical Engineering, Serbia) , Senka Vidović (University of Novi Sad, Novi Sad, Faculty of Technology, Department of Biotechnological and Pharmaceutical Engineering, Serbia)
The influence of Satureja montana extracts on several liver biochemical parameters in mice administered with carbon tetrachloride was estimated. In vivo investigation of antioxidant properties of S. montana extracts encompassed monitoring of biochemical parameters (derived from liver homogenate and blood hydrolyzate) and examination of potential hepatoprotective effect after intoxication with carbon tetrachloride. Biochemical tests included determination of activity of several antioxidant enzymes: xanthine oxidase, catalase, peroxidase, glutathione peroxidase, amount of reduced glutathione and intensity of lipid peroxidation. In order to obtain data about the potent hepatoprotective effect of examined extracts, the following parameters were determined: aspartate aminotransferase, alanine aminotransferase, bilirubin, hepatic DNA and hydroxyprolin. Results of this study demonstrate that S. montana extracts inhibited the hepatotoxicity produced by carbon tetrachloride administration most probably through activation of physiological common defense mechanisms.
Keywords: Satureja montana, hepatoprotective, antioxidant
How to Cite: Ćebović, T. , Vladić, J. , Gavarić, A. , Zekanović, Z. & Vidović, S. (2019) “Assessment of antioxidant and hepatoprotective potential of Satureja montana extracts against CCl4 induced liver damage”, Lekovite Sirovine. 39(1). doi: https://doi.org/10.5937/leksir1939005c