Phyto-pharmacological aspects of Nepeta nuda L.: A systematic review

Milica Aćimović, Jovana Stanković Jeremić, Mirjana Cvetkovic

DOI: http://dx.doi.org/10.5937/leksir2040075A

Abstract


Nepeta nuda L. (syn. N. pannonica L.) is a herbaceous perennial plant, is the most widespread species of the genus Nepeta, the largest genera in Lamiaceae family. However, N. nuda is well spread worldwide, and divided into four subspecies according to morphological differences which occur within large geographical range of distribution: subsp. nuda, subsp. albiflora, subsp. lydiae and subsp. glandulifera. In this review, previous reports on N. nuda concerningits botanical description and systematics, phytochemistry, use in traditional medicine, pharmacology, and posibilities for other applications were critically summarized. This paper includes data about N. nuda phytochemical compounds, ethnomedicinal uses, pharmacological properties, and prospect of it being applied as a natural herbicide an in management of plant diseases. All of this contributes to N. nuda being a highly promising plant in food and pharmaceutical industries, as well as in agriculture for the development of natural pesticides.

Keywords


Nepeta pannonica, subspecies, essential oil, phytochemistry, pharmacology

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References


Alim, A., Goze, I., Cetin, A., Atas, A.D., Cetinus, S.A., Vural N. (2009). Chemical composition and in vitro antimicrobial and antioxidant activities of the essential oil of Nepeta nuda L. subsp. albiflora (Boiss.) Gams, African Journal of Microbiology Research 3(8): 463-467.

Angelova, P., Hinkov, A., Tsvetkov, V., Shishkova, K., Todorov, D., Shishkov S. (2016). Inhibition of human herpes virus type 2 replication by water extract from Nepeta nuda L., Acta Microbiologica Bulgarica 32(2): 148-149.

Aničić, N., Matekalo, D., Skorić, M., Nestorović Živković, J., Petrović, L., Dragićević, M., Dmitrović, S., Mišić, D. (2020). Alterations in nepetalactone metabolism during polyethylene glycol (PEG)-induced dehydration stress in two Nepeta species, Phytochemistry 174: 112340.

Aras, A., Bursal, E., Dogru, M. (2016a). UHPLC-ESI-MS/MS analyses for quantification of phenolic compounds of Nepeta nuda subsp. lydiae. Journal of Applied Pharmaceutical Science, 6(11): 9-13.

Aras, A., Dogru, M., Bursal, E. (2016b). Determination of antioxidant potential of Nepeta nuda subsp. lydiae, Analytical Chemistry Letters 6(6): 758-765.

Bidgoli, R.D., Azarnezhad, N., Akhbari, M., Ghorbani, M. (2019). Salinity stress and PGPR effects on essential oil changes in Rosmarinus officinalis L., Agriculture and Food Security 8: 2.

Birkett, M.A., Bruce, T.J.A., Pickett, J.A. (2010). Repellent activity of Nepeta grandiflora and Nepeta clarkei (Lamiaceae) against the cereal aphid, Sitobion avenae (Homoptera: Aphididae), Phytochemistry Letters 3: 139-142.

Boikova, O.I., Grishkina, K.A. (2019a). Content of kumarins in Nepeta pannonica growing in the Tula region, Проблемы Научной Мысли 7(3): 9-11.

Boikova, O.I., Grishkina, K.A. (2019b). Content is of tannins of the Nepeta pannonica growing in Tula region, Проблемы Научной Мысли 7(3): 12-14.

Bozari, S., Agar, G., Aksakal, O., Erturk, F., Yanmis, D. (2012). Determination of chemical composition and gentoxic effects of essential oil obtained from Nepeta nuda on Zea mays seedlings, Toxicology and Industrial Health, DOI:10.1177/0748233711433939

Bozek, M. (2003). Pollen efficiency and foraging by insect pollinators in three catnip (Nepeta L.) species, Journal of Apicultural Science 47(2): 19-24.

Bozok, F., Cenet, M., Sezer, G., Ulukanli, Z. (2017). Essential oil and bioherbicidal potential of the aerial parts of Nepeta nuda subsp. albiflora (Lamiaceae). Journal of Essential Oil Bearing Plants 20(1): 148-154.

Chalchat, J.C., Petrovic, S.D., Gorunovic, M.S. (1998). Quantity and composition of essential oil of the wild plant Nepeta nuda L. from Yugoslavia, Journal of Essential Oil Research 10: 423-425.

Chan, W.K., Tan, L.T.H., Chan, K.G., Lee, L.H., Goh, B.H. (2016). Nerolidol: a sesquiterpene alcohol with multi-facted pharmacological and biological activities, Molecules 21(5): 529.

Cvetković, J., Milutinović, M., Boljević, J., Aničić, N., Nestorović Živković, J., Živković, S., Mišić, D. (2015). Paraquat-mediated oxidative stress in Nepeta pannonica L., Botanica Serbica 39(2): 121-128.

Dirmenci, T. (2005). A new subspecies of Nepeta (Lamiaceae) from Turkey, Botanical Journal of the Linnean Society 147: 229-233.

Đorđević, S., Stanisavljević, D., Milenković, M., Karabegović, I., Lazić, M., Nikolova, M., Veličković, D. (2019). Formulation of refreshing non-alcoholic beverage with extracts of medicinal plants, Progress in Nutrition 21(3): 620-630.

Dragoeva, A., Stoyanova, Z., Koleva, V., Dragolova, D. (2017). Allelopathic activity of Nepeta nuda L. subsp. nuda water extracts, Acta Scientifica Naturalis 4(1): 46-51.

Dragolova, D., Stefanova, M., Dimitrova, M., Koleva, D., Zhiponova, M., Kapchina-Toteva, V. (2015). In vitro cultivation and ex vitro adaptation of Nepeta nuda ssp. nuda – correlation between regeneration potential, leaf anatomy, and plastid pigments, Bulgarian Journal of Agricultural Science 21(5): 1027-1032.

Duda, S., Mărghitaş, L., Dezmirean, D., Bobiş, O., Duda, M. (2014). Nepeta cataria – medicinal plant of interest in phytotherapy and beekeeping, Hop and Medicinal Plants 22(1-2): 34-38.

Duda, M.M., Imbrea, F., Varban, D., Muntean, S. (2010). Research on values of 1000 seeds weight in some medicinal plants, Research Journal of Agricultural Science 42(1): 101-104.

Eisenman, S., Zaurov, D., Struve, L. (2013). Medicinal Plants of Central Asia: Uzbekistan and Kyrgyzstan, Springer.

Erdag, B., Emek, Y. (2018). In vitro propagation of Nepeta nuda subsp. lydiae Ph Davis, International Journal of Herbal Medicine, 6(6): 106-109.

Erdag, B., Emek, Y., Kuzu, I., Bagdatl, N. (2018). Axillary shoot proliferation from aseptic seedlings of Nepeta nuda subsp. albiflora, Journal of Medicinal plants Studies 6(3): 34-37.

Fairlie, J., Hodgson, H., Money, T. (1973). Synthesis of (±)-camphor, Journal of the Chemical Society Perkin Translactions 1(19): 21092112.

Formisano, C., Rigano, D., Senatore F. (2011). Chemical constituents and biological activities of Nepeta species, Chemistry and Biodiversity 8: 1783-1818.

Ghendov, V., Ciocarlan, N., Danila, D. (2015). Bio-ecological pecularities of Nepeta panonica L. under in situ and ex situ conditions, Journal of Botany 2(11): 35-39.

Gkinis, G., Bozin, B., Mimica-Dukic, N., Tzakou, O. (2010). Antioxidant activity of Nepeta nuda L. ssp. nuda essential oil rich in nepetalactones from Greece, Journal of Medicinal Food 13(5): 1176-1181.

Gormez, A., Bozari, S., Yanmis, D., Gulluce, M., Agar, G., Sahin, F. (2013). Antibacterial activity and chemical composition of essential oil obtained from Nepeta nuda against phytopathogenic bacteria. The Essential Oil Research 25(2): 149-153.

Hadi, N., Sefidkon, F., Shojaeiyan, A., Šiler, B., Jafari, A.A., Aničić, N., Mišić, D. (2017). Phenolics’ composition in four endemic Nepeta species from Iran cultivated under experimental field conditions: The possibility of the exploitation of Nepeta germplasm, Industrial Crops and Products 95: 475-484.

Handjieva, N., Popov, S., Evstatieva, Lj. (1996). Constituents of essential oils from Nepeta cataria L., N. grandiflora M.B. and N. nuda L., Journal of Essential Oil Research 8: 639-643.

Hassan, T., Rather, M.A., Sofi, S.N., Dar, B.A., Dar, G.H. (2011). GC-FID and GC-MS analysis of the sesquiterpene rich essential oil of Nepeta govaniana (Wall. ex Benth.) Benth. from Jammu and Kashmir, International Journal of ChemTech Research 3(3): 1194-1199.

Haydari, M., Maresca, V., Rigano, D., Taleei, A., Shahnejat-Bushehri, A.A., Hadian, J., Sorbo, S., Guida, M., Manna, C., Piscopo, M., Notariale, R., Ruberto, F.D., Fusaro, L., Basile, A. (2019). Salicylic acid and melatonin alleviate the effects of heat stress on essential oil composition and antioxidant enzyme activity in Mentha × piperita and Mentha arvensis L., Antioxidants (Basel) 8(11): 547.

Josifović, M. (1975). Flora SR Srbije, Tom 6. Srpska akademija nauke i umetnosti, Beograd.

Kabalay, B., Mutlu, D., Arslan, S., Semiz, G., Kocabiyik, K. (2018). Chemical composition and cytotoxicity of Nepeta nuda subsp. lydiae P. H. Davis essential oil towards colon carcinoma, The 4th International Symposium EuroAsian Diversity, 154 pp., Kiev, Ukraine.

Kilic, O., Hayta, S., Bagci, E. (2011). Chemical composition of essential oil of Nepeta nuda L. subsp. nuda (Lamiaceae) from Turkey, Asian Journal of Chemistry 23(6): 2788-2790.

Kofidis, G., Bosabalidis, A. (2008). Effects of altitude and season on glandular hairs and leaf structural traits of Nepeta nuda L., Botanical Studies 49: 363-372.

Kokdil, G., Kurucu, S., Topcu, G. (1996). Composition of the essential oil of Nepeta nuda L. ssp. albiflora (Bioss.) Gams., Flavour and Fragance Journal 11: 167-169.

Kokdil, G., Kurucu, S., Yildiz, A. (1998). Essential oil composition of Nepeta nuda L. ssp. nuda, Flavour and Fragance Journal 13: 233-234.

Kokdil, G., Yalcin, S., Topcu, G. (1999). Nepetalactones and other constituents of Nepeta nuda ssp. albiflora, Turkish Journal of Chemistry 23: 99-104.

Kokkini, S., Babalonas, D. (1982). Morphological variation in Nepeta nuda L., Feddes Repositorium 93(1-2): 71-76.

Kozuharova, E., Benbassat, N., Getov, I. (2014). Ethnobotanical records of not yet documented therapeutic effects of some popular Bulgarian medicinal plants, Emirates Journal of Food and Agriculture 26(7): 647-651.

Ljaljević Grbić, M., Stupar, M., Vukojević, J., Soković, M., Mišić, D., Grubišić, D., Ristić, M. (2008). Antifungal activity of Nepeta rtanjensis essential oil, Journal of the Serbian Chemical Society 73(10): 961-965.

Mancini, E., Arnold, N.A., Feo, V.D., Formisano, C., Rigano, D., Piozzi, F., Senatore, F. (2009). Phytotoxic effect of essential oils of Nepeta curviflora Boiss. and Nepeta nuda L. subsp. albiflora growing wild in Lebanon, Journal of Plant Interactions 4(4): 253-259.

Matejić, J., Šarac, Z., Ranđelović, V. (2010). Pharmacological activity of sesquiterpene lactones, Biotechnology and Biotechnological Equipment 24: 95-100.

Narimani, R., Moghaddam, M., Pirbalouti, A.G., Mojarab, S. (2017). Essential oil composition of seven populations belonging to two Nepeta species from Northwestern Iran, International Journal of Food Properties 20(52): S2272-2279.

Ozcan, T. (2019). Micromorphological comparison of Nepeta viscida, N. nuda subsp. nuda and their putative hybrids N. × tmolea. Jornal of Balikesir University Institute of Science and Technology 21(1): 30-42.

Pooter, H., Nicolai, B., De Buyck, L., Goetghebeur, P., Schamp, N. (1987). The essential oil of Nepeta nuda. Identification a new nepetalactone diastereoisomer, Phytochemistry 26(8): 2311-2314.

Sarer, E., Konuklugil, B. (1996). Composition of the essential oil from Nepeta nuda ssp. albiflora (Boiss.) Gams., Journal of Essential Oil Research 8: 687-688.

Sarikurkcu, C., Ceylan, O., Targan, S., Ćavar Zeljković, S. (2018). Chemical composition and biological activities of the essential oils of two endemic Nepeta species, Industrial Crops and Products 125: 5-8.

Sarikurkcu, C., Eskici, M., Karanfil, A., Tepe, B. (2019). Phenolic profile, enzyme inhibitory and antioxidant activities of two endemic Nepeta species: Nepeta nuda subsp. glandulifera and N. cadmea, South African Journal of Botany 120: 298-301.

Sharifi-Rad, J., Sureda, A., Tenore, G.C., Daglia, M., Sharifi-Rad, M., Valussi, M., Tundis, R., Sharifi-Rad, M., Loizzo, M.R., Ademiluyi, A.O., Sharifi-Rad, R., Ayatollahi, S.A., Iriti, M. (2017). Biological activities of essential oils: from plant chemoecology to traditional healing systems, Molecules 22(1): 70.

Smiljković, M., Dias, M.I., Stojković, D., Barros, L., Bukvički, D., Ferreira, I.C.F.R., Soković, M. (2018). Characterization of phenolic compounds in tincture of edible Nepeta nuda: development of antimicrobial mouthwash, Food and Function, DOI: 10.1039/C8FO01466C.

Suntar, I., Nabavi, S.M., Barreca, D., Fisher, N. 2018. Pharmacological and chemical features of Nepeta L. genus: its importance as therapeutic agent, Phytotherapy Research 32: 185-198.

Tabata, M. (1977). Recent advances in the production of medicinal substances by plant cell cultures, Plant Tissue Culture and Its Bio-technological Application: Proceedings of the First International Congress on Medicinal Plant Research.

Takeda, Y., Morimoto, Y., Matsumoto, T. (1995). Nepetanudoside, an iridoid glucoside with an unusual stereostructure from Nepeta nuda ssp. albiflora, Journal of Natural Products 58(8): 1217-1221.

Takeda, Y., Yagi, T., Matsumoto, T., Honda, G., Tabata, M., Fujita, T., Shingu, T., Otsuka, H., Sezik, E., Yesilada, E. (1996). Nepetanudosides and iridoid glucosides having novel stereochemistry from Nepeta nuda ssp. albiflora, Phytochemistry 42(4): 1085-1088.

Todorov, D., Shishkova, K., Dragolova, D., Hinkov, A., Kapchina-Toteva, V., Shishkov, S. (2015). Antiviral activity of medicinal plant Nepeta nuda, Biotechnology and Biotechnological Equipment 29: S39-S43.

Vladimirov, V., Dane, F., Stevanović, V., Tan, K. (2013). New floristic records in the Balkans: 22, Phytologia Balcanica 19(2): 267-303.

Wieteska, A., Jadczak, D., Wesolowska, A. (2018). Comparison of the biological value of selected catnip plant (Nepeta sp.), Asian Journal of Medicinal Plants 6(7): 191-195.

Zomorodian, K., Saharkhiz, M.J., Shariati, S., Pakshir, K., Rahimi, M.J., Khashei, R. (2012). Chemical composition and antimicrobial activities of essential oils from Nepeta cataria L. against common causes of food-borne infections, ISRN Pharmaceutics 2012: 591953.


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