Antiviral activity of medicinal plants extracts against foodborne norovirus

Ivana Živković, Katarina Šavikin, Gordana Zdunić, Jelena Živković, Dubravka Bigović, Nebojša Menković, Dragoslava Radin



Medicinal plant extracts have a broad antimicrobial activity, including antiviral effects. In our study, eleven dry extracts of ten different medicinal plants prepared with two solvents (5%, dimethyl sulfoxide (DMSO) and 30% ethanol in 5% DMSO) in different concentrations have been examined for anti-norovirus activity. The reduction of norovirus >1 log10 genome equivalents has been obtained with 1 mg/mL of Aronia melanocarpa leaf extract, dried wine Prokupac and Hypericum perforatum extract. Some of the observed extracts i.e. Hypericum perforatum, Aronia melanocarpa fruit extract and Punica granatum peel extract showed better activity when dissolved in 30% ethanol with 5% DMSO. All results of anti-noroviral activity of tested extracts which achieved <0.5 log10 genome equivalents were considered as not effective.


Human norovirus, medicinal plant extract, antiviral activity

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