Research Article

High doses of Uvaria chamae root extract impair sperm motility and viability

Authors: Godwin Adakole Ujah (University of Calabar, Department of Physiology, Calabar, Nigeria) , Ileri-Oluwa Busayo Emmanuel (Forestry Research Institute of Nigeria, Biomedicinal Research Centre, Ibadan, Nigeria) , Bassey Emmanuel Emeng (University of Calabar, Department of Physiology, Calabar, Nigeria) , Patience Favour Kalu (University of Calabar, Department of Physiology, Calabar, Nigeria)

  • High doses of Uvaria chamae root extract impair sperm motility and viability

    Research Article

    High doses of Uvaria chamae root extract impair sperm motility and viability

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Abstract

Uvaria chamae is a tropical medicinal plant with documented antimicrobial and antimalarial activities. Agents with these activities are known to impair fertility. This study investigated the antifertility effects of ethanolic extract of U. chamae on male albino Wistar rats. Two different oral doses; 56.6 mg/kg body weight and 113.2 mg/kg body weight of the extracts were administered to low dose and high dose group, respectively. A third group served as control and received 2 mL of distilled water. There were five animals in each group. Administration lasted six weeks after which animals were sacrificed and samples collected. Results showed that sperm count, sperm morphology and semen pH were not affected (P>0.05) by the extract. Sperm motility (55.65 %) and viability (64.38 %) were however decreased (P<0.05) by high doses of the extract. Histopathology of testicular tissues also showed no difference across the groups. U. chamae thus impair fertility in vivo especially at high doses.

Keywords: Uvaria chamae, fertility, sperm motility, viability

How to Cite:

Ujah, G. A., Emmanuel, I. B., Emeng, B. E. & Kalu, P. F., (2021) “High doses of Uvaria chamae root extract impair sperm motility and viability”, Lekovite Sirovine 41(1), 58-62. doi: https://doi.org/10.5937/leksir2141058u

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Published on
2021-12-25

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Creative Commons Attribution 4.0